Soluble Triggering Receptor Expressed on Myeloid Cells 2 is a Biomarker but Not a Mediator of Fibrosing Steatohepatitis.

ABSTRACT:

Background and aims

Triggering receptor expressed on myeloid cells 2 (TREM2), a transmembrane, lipid-sensing protein expressed by Kupffer cells, is thought to play a role in metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Plasma levels of the TREM2 cleavage product, soluble TREM2 (sTREM2), are strongly associated with MASLD severity. We investigated the role of TREM2 in MASH pathogenesis and whether sTREM2 acts both as biomarker and mediator of MASH.

Methods

Adult C57BL/6J mice were assigned to normal, high-fat, or high-fat and high-cholesterol (HFHC) diets for 15, 30, 90, and 180 days. Plasma sTREM2 levels, liver pathology, and hepatic RNA expression were assessed. To test whether sTREM2 is a medi

SUBMITTER: Dempsey JL 

PROVIDER: S-EPMC12681988 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature