Exploring reductive stress as a regulation approach for <i>Pseudomonas Aeruginosa</i> biofilm.

ABSTRACT: Pseudomonas aeruginosa (P. aeruginosa) biofilms pose substantial challenges in clinical settings due to their resistance to conventional antibiotic treatments. This study investigated the influence of reductive stress on the formation and eradication of P. aeruginosa biofilms. A series of redox-active compounds were employed to assess their impact on both biofilm development and disruption. Among them, hydrazine (HZ) showed potent activity. Mechanistic studies revealed that these compounds suppressed pyocyanin production and impaired bacterial metabolic activity. A structure-activity relationship analysis highlighted hydroxylamine (HA) as a promising candidate, owing to its favorable balance between efficacy and cytotoxicity. Notably, quantitative reverse transcription

SUBMITTER: Liu J 

PROVIDER: S-EPMC12682017 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature