One-stop early noninvasive evaluation of renal allograft rejection and fibrosis: microstructural mapping via time-dependent diffusion MRI.

ABSTRACT:

Background

Functional MRI offers promise for noninvasive detection of renal allograft injury, but conventional models lack biological specificity. This study aimed to evaluate the clinical utility of time-dependent diffusion MRI (td-dMRI) for detecting rejection and fibrosis in renal allografts.

Methods

In this prospective observational study at a tertiary center in China, adult patients with renal allograft undergoing indication biopsies between April 2024 and June 2025 were enrolled. Microstructural maps were derived from td-dMRI, intravoxel incoherent motion, diffusion kurtosis imaging, stretched exponential model, fractional order calculus, and continuous-time random-walk model. To address overfitting risk from limited samples, final multivariate models were constructed

SUBMITTER: Liao Z 

PROVIDER: S-EPMC12682057 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature