Neuroimaging signatures of mesial temporal lobe epilepsy: A coordinate-based meta-analysis of structural and resting-state functional imaging literature.

ABSTRACT: Mesial temporal lobe epilepsy (MTLE) seizures are known to alter neural architecture, yet imaging studies report conflicting findings of their effects on the brain. This study aimed to identify consistent regions exhibiting structural or functional changes in MTLE and compare the regional distributions of pathology detected by different neuroimaging modalities. To that end, thirty-six coordinate-based meta-analyses were performed by applying Alteration Likelihood Estimation to voxel-based morphometry (VBM) and voxel-based physiology (VBP) studies. The meta-analyses revealed convergent MTLE pathology in the epileptogenic hippocampus, bilateral thalamus (medial dorsal nucleus and pulvinar), and striatum (caudate and putamen); significant findings were partially colocalized between VBM-atroph

SUBMITTER: Towne JM 

PROVIDER: S-EPMC12682080 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature