Shared metabolomic signatures for prognostic precision across brain injuries.

ABSTRACT:

Introduction

Metabolomic alterations have been linked to a range of neurological conditions. Investigating temporal changes in serum metabolomic profiles, regardless of the type of brain injury may reveal prognostic indicators.

Research question

We hypothesize that specific metabolomic signatures, conserved across different acute brain injuries, can serve as robust predictors of patient outcomes.

Material and methods

In this longitudinal prospective observational study, serum samples were collected early (2 ± 1 day) and late (6 ± 2 days) post-injury from a total of 73 patients with ischemic stroke (n = 30), aneurysmal subarachnoid hemorrhage (n = 30), and traumatic brain injury (n = 13). Outcomes were categorized as favorable (modified Rankin Scores (mRS) 0-3) and unf

SUBMITTER: Hellstrom S 

PROVIDER: S-EPMC12682153 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature