Serrated polyps in the colorectum: clinical significance and future directions.

ABSTRACT: Serrated polyps are believed to play an important role in the development of colorectal cancer (CRC). They share molecular characteristics and proximal colonic location with postcolonoscopy colorectal cancer (PCCRC), indicating that they may give rise to a disproportionately high proportion of PCCRC. In this narrative literature review, we aimed to synthesise the current understanding of serrated polyps and their role in the development of CRC. Our review focuses on the prevalence of serrated lesions in various populations, risk of progression to advanced colorectal neoplasia and cancer, and the effect of serrated polyp detection on PCCRC rates. Serrated polyp detection is noted to be variable between studies based on the type of serrated polyps studied and the patient population in questi

SUBMITTER: Mallick TR 

PROVIDER: S-EPMC12682197 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature