Molecular interactions of the Na_V1.5 C-terminal domain: CaM sequestered the IQ motif from the CTD.

ABSTRACT: Voltage-gated sodium channels (Na_V) are important for life. Alterations to the synchronized timing of ion conduction can create life-threatening conditions. How Na_V conduction responds to changes in intracellular Ca²⁺ concentration has been the subject of extensive investigation. Crystal structures of the cardiac Na_V (Na_V1.5) cytosolic components were reported as trimeric complexes that are restructured in the presence of Ca²⁺. These results formed the basis for a gating model where two Na_V1.5 molecules interact to alter function in response to Ca²⁺ concentration. Here, we investigated the binding site surface of these trimeric interactions in solution. Nuclear magnetic resonance spectroscopy demonstrat

SUBMITTER: Gyawu RF 

PROVIDER: S-EPMC12682251 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature