Overexpressed CD24 and CD47 Indicate a Worse Prognosis in Cervical Cancer.

ABSTRACT:

Background

Two antiphagocytic ("don't eat me") signals that allow tumor immune evasion have been discovered, including CD24 and CD47. This study explored the association between CD24/CD47 expression and macrophage infiltration and clinical outcomes in cervical cancer.

Methods

RNA expression and survival data of the Cancer Genome Atlas (TCGA) cohort were extracted from OncoLnc. The macrophage infiltration level was calculated using xCell, TIMER, and ImmuCellAI. The expression of CD24 and CD47 was detected by immunohistochemistry in tissue microarrays composed of 130 clinical cervical cancer specimens from Fudan University Shanghai Cancer Center (FUSCC). Patients' medical records were also retrospectively assessed to correlate demographic and survival data.

Results

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SUBMITTER: Yu M 

PROVIDER: S-EPMC12682362 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature