Treatment exposure-based risk-stratification for care of survivors of childhood cancer: a report from the childhood cancer survivor study.

ABSTRACT:

Background

Treatment exposure-based risk-stratification of long-term cancer survivors may help inform health care in survivorship clinics. We used the large, diverse population of the Childhood Cancer Survivor Study to test a modified, exposure-based strata previously developed within United Kingdom to classify survivors with respect to risk of late morbidity and health-related mortality.

Methods

Five-year survivors of childhood cancer were categorized into low-, medium-, and high-risk groups based on treatment exposures and diagnosis. Primary endpoints included cumulative health-related (ie, nonrecurrence, nonexternal) late mortality and cumulative incidence of severe or fatal (CTCAE grade 3-5) chronic health conditions conditional on reaching age 20 without the outcome. Si

SUBMITTER: Dinan MA 

PROVIDER: S-EPMC12682367 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature