Sex-specific body fat distribution predicts cardiovascular ageing.

ABSTRACT:

Background and aims

Cardiovascular ageing is a progressive loss of physiological reserve, modified by environmental and genetic risk factors, that contributes to multi-morbidity due to accumulated damage across diverse cell types, tissues, and organs. Obesity is implicated in premature ageing, but the effect of body fat distribution in humans is unknown. This study determined the influence of sex-dependent fat phenotypes on human cardiovascular ageing.

Methods

Data from 21 241 participants in the UK Biobank were analysed. Machine learning was used to predict cardiovascular age from 126 image-derived traits of vascular function, cardiac motion, and myocardial fibrosis. An age-delta was calculated as the difference between predicted age and chronological age. The volume and di

SUBMITTER: Losev V 

PROVIDER: S-EPMC12682380 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature