Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis.

ABSTRACT:

Introduction

There is convincing evidence that overall adiposity increases the risks of several cancers. Whether the distribution of adiposity plays a similar role is unclear.

Methods

We used 2-sample Mendelian randomization (MR) to examine causal relationships of 5 adiposity distribution traits (abdominal subcutaneous adipose tissue (ASAT); visceral adipose tissue (VAT); gluteofemoral adipose tissue (GFAT); liver fat; and pancreas fat) with the risks of 12 obesity-related cancers (endometrial, ovarian, breast, colorectal, pancreas, multiple myeloma, liver, kidney (renal cell), thyroid, gallbladder, esophageal adenocarcinoma, and meningioma).

Results

Sample size across all genome-wide association studies (GWAS) ranged from 8407 to 728 896 (median: 57 249). We found ev

SUBMITTER: Hazelwood E 

PROVIDER: S-EPMC12682385 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature