Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer.

ABSTRACT:

Background

Cancer-related fatigue (fatigue) is a common and persistent symptom after cancer treatment, yet the role of genetic susceptibility remains unclear.

Methods

We used data from a prospective cohort study called the ColoCare Study, conducted over 5 US sites and Germany. Fatigue was assessed at 5 time points using the European Organisation for the Research and Treatment of Cancer Core Quality of Life Questionnaire fatigue subscale and analyzed as (1) a binary summary measure of the trajectory from diagnosis into survivorship (defined as severe: yes/no), (2) a mean score across all time points, and (3) the highest (ie, worst) score across all time points. We genotyped samples using the Illumina Infinium Global Diversity Array kit with imputation using the National Insti

SUBMITTER: Kazemian E 

PROVIDER: S-EPMC12682389 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature