Pretreatment Amide Proton Transfer-Weighted Imaging Histogram Analysis Combined With ER-Negative and HER2-Positive Expression Predicts Pathologic Complete Response After Neoadjuvant Chemotherapy in Breast Cancer.

ABSTRACT:

Purpose

To evaluate the predictive value of pre-treatment histogram analysis using APTWI, diffusion-weighted imaging (DWI), and early contrast-enhanced silhouette imaging in determining pathological complete response (pCR) post-NAC in breast cancer, and to investigate whether combining immunohistochemical indicators enhances predictive accuracy.

Materials and methods

A retrospective continuous collection of 108 females with breast cancer who underwent NAC and pre-treatment APTWI, DWI, and dynamic contrast-enhanced imaging at our hospital. Clinical, MRI imaging, and pathological characteristics were analyzed for patients. NAC response was divided into pCR and non-pCR. Tumor segmentation and histogram feature extraction were performed on APT, ADC, and early contrast-enhanced s

SUBMITTER: Xu M 

PROVIDER: S-EPMC12682392 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature