STIM1 Reduction Prevents Tubular Aggregate Formation and Compromises Muscle Performance in Ageing Mice.

ABSTRACT:

Background

Ageing is an irreversible process involving the gradual decline of cellular functions in all tissues. In male mice, age-related loss of muscle force is accompanied by the formation of tubular aggregates, which are honeycomb-like structures composed of membrane tubules, proteins and Ca²⁺ deposits. Tubular aggregates are also found in tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK), two clinically overlapping human disorders affecting skeletal muscle, bones, skin, spleen and platelets. TAM/STRMK is caused by gain-of-function mutations in the ubiquitously expressed Ca²⁺ sensor STIM1 and results in excessive extracellular Ca²⁺ entry and the dysregulation of Ca²⁺ homeostasis.

Methods

To understand the correla

SUBMITTER: Perez-Guardia L 

PROVIDER: S-EPMC12682393 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature