Functional lung avoidance stereotactic body radiation therapy for central lung cancer patients.

ABSTRACT:

Background

To improve patients' quality of life, it is necessary to preserve the high-functioning regions of the lung. This study aimed to propose a planning strategy that prioritizes sparing ventilation function for stereotactic body radiation therapy (SBRT) in patients with central lung cancer.

Methods

Twenty patients with central lung cancer were retrospectively enrolled. Ventilation maps were obtained from 4-dimensional computed tomography by deformable image registration and quantitative analysis. The top 60% and 30-60% of the total lung were defined as high- and medium-ventilation regions, respectively. Clinical plans and functional lung avoidance (FLA) plans were designed for each patient, and FLA plans were optimized to spare high-ventilation (H-V) regions. Dosimetri

SUBMITTER: Feng A 

PROVIDER: S-EPMC12682476 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature