Ultrasound molecular imaging in evaluating the severity of ischemia-reperfusion injury-induced acute kidney injury.

ABSTRACT:

Background

Acute kidney injury (AKI) is a global public health issue for which the prognosis varies, depending on the severity. Early and accurate assessment of the severity of AKI is crucial for determining the prognosis of patients. Ultrasound molecular imaging (USMI) technology can be used to evaluate AKI, but studies on assessing the inflammatory responses of different severity levels of AKI have not been reported. Therefore, this study aimed to explore the early value of USMI technology based on vascular cell adhesion molecule-1 (VCAM-1) targeted microbubbles in monitoring the severity of AKI at the molecular level.

Methods

A total of 66 mice were randomly divided into a mild ischemia-reperfusion injury (IRI)-AKI (m-AKI) group, severe IRI-AKI (s-AKI) group, and sham ope

SUBMITTER: Ren L 

PROVIDER: S-EPMC12682484 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature