Altered intra- and inter-network functional connectivity in pituitary adenomas with chiasmal compression.

ABSTRACT:

Background

Pituitary adenomas (PA) frequently compress the optic chiasm, leading to visual field defects (VFDs) and potentially affecting the function of brain networks. This cross-sectional study aimed to investigate alterations in brain networks in PA patients with chiasmal compression using resting-state functional magnetic resonance imaging (rs-fMRI).

Methods

In this study, 35 PA patients with chiasmal compression and 33 healthy controls (HCs) were enrolled and underwent rs-fMRI scanning. Network-Based Statistic (NBS) and large-scale network analyses were performed. Additionally, correlations were analyzed between altered functional connectivity (FC) and suprasellar extension distance, duration of VFDs, as well as mean deviation (MD), reflecting the degree of VFDs.

Re

SUBMITTER: Tang J 

PROVIDER: S-EPMC12682495 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature