Creation of structural MRI brain templates for middle to late adulthood in the Thai population using single and multi-scanner data.

ABSTRACT:

Background

The global increase in elderly populations, particularly in low- and middle-income countries, underscores the rising prevalence of age-related conditions, such as Alzheimer's disease. Structural magnetic resonance imaging (MRI) plays a crucial role in Alzheimer's disease research and early diagnosis; however, manual brain segmentation is labor-intensive, time-consuming, and prone to inter-rater variability. Automated segmentation using existing brain templates from Mongoloid, Caucasoid, and Negroid populations may not be suitable for Thai individuals due to anatomical differences, emphasizing the need for population-specific templates. This study aimed to develop structural MRI brain templates tailored for cognitively normal Thai adults aged 50-70 years, using both singl

SUBMITTER: Pinyopornpanish K 

PROVIDER: S-EPMC12682506 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature