Age-related bone mass and body composition dynamics in female cynomolgus monkeys: dual-energy X-ray absorptiometry insights for osteoporosis etiology.

ABSTRACT:

Background

Osteoporosis, characterized by reduced bone mass and increased fracture risk, is a major global health burden. Nonhuman primates, particularly female cynomolgus monkeys, are critical preclinical models due to their skeletal and hormonal similarity to humans. Dual-energy X-ray absorptiometry (DXA) is the gold standard for measuring bone mineral density (BMD) and body composition. However, data on age-related changes in these metrics in cynomolgus monkeys are inconsistent, and the relationship between body composition and BMD remains debated and understudied in this model. The objectives of this study were to delineate the age-dependent trends in bone mass and body composition and to evaluate the impact of body composition on bone mass. This study aims to furnish a data re

SUBMITTER: Cai Q 

PROVIDER: S-EPMC12682510 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature