Disrupted intrinsic functional brain topology in patients with basal ganglia ischemic stroke.

ABSTRACT:

Background

Ischemic stroke affecting the basal ganglia disrupts motor, cognitive, and emotional functions, yet the underlying neural network mechanisms remain poorly understood. This study aimed to investigate alterations in brain network topology in patients with acute basal ganglia ischemic stroke (BGIS) through use of resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory analysis (GTA).

Methods

We constructed whole-brain functional networks and analyzed global and local topological properties in 82 patients with acute BGIS and compared them those in 83 healthy controls (HCs) using the Dosenbach atlas.

Results

Both groups retained small-world attributes (Sigma >1). However, patients with BGIS exhibited significantly lower normalized clusteri

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12682516 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature