Left ventricular sphericity indexes by gated single photon emission computed tomography myocardial perfusion imaging: potential opportunities and challenges for cardiac remodeling and clinical prognosis-a narrative review.

ABSTRACT:

Background and objective

Left ventricular (LV) remodeling is a crucial process in cardiac pathophysiology, significantly influencing the progression of heart failure (HF). LV sphericity indexes (LVSI), which include the shape index (SI) and eccentricity index (EI), are derived from gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (G-MPI) and are emerging as essential biomarkers for assessing LV remodeling (LVR). This review aims to summarize the imaging principles of LVSI and explore the pathophysiological insights and clinical applications associated with these indexes.

Methods

A comprehensive literature search was conducted to identify relevant publications pertaining to LVSI. PubMed was searched for articles published using a combinati

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12682518 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature