Preoperative risk stratification of colorectal high-grade intraepithelial neoplasia based on endoscopic biopsy: superior performance of ¹⁸F-FDG positron emission tomography-computed tomography over contrast-enhanced computed tomography in guiding surgical decision-making.

ABSTRACT:

Background

High-grade intraepithelial neoplasia (HGIN) is the stage at which high-grade dysplasia is present but there is no invasion beyond the muscularis. Endoscopic forceps biopsy (EFB) is the gold standard for the histological diagnosis of colorectal epithelial neoplasia. However, histopathologic discrepancy exists between EFB and postresection specimens. This study aimed to compare the diagnostic accuracy and clinical utility of positron emission tomography-computed tomography (PET/CT) with those of contrast-enhanced computed tomography (CECT) in optimizing the preoperative decision-making for surgical intervention in patients with HGIN diagnosed endoscopically.

Methods

The study examined 83 lesions, 30 of which underwent both PET/CT and CECT imaging. Demographic data,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12682525 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature