Dosimetric impact of bladder volume variation on online adaptive radiotherapy for cervical cancer based on cone-beam computed tomography and clinical management strategies.

ABSTRACT:

Background

During cervical cancer radiotherapy, unstable bladder volume can compromise target accuracy and increase radiation exposure to organs at risk (OARs). Although online adaptive radiotherapy (ART) can correct for interfractional variations, intrafractional bladder filling may still lead to dose deviations. This study aimed to evaluate the dosimetric optimization of ART for interfractional bladder fluctuations, analyze the impact of intrafractional dynamics, and evaluate the clinical benefits of personalized bladder management.

Methods

Fourteen patients with cervical cancer receiving radical radiotherapy with a prescription dose of 45-50 Gy/25 fractions from December 2023 to July 2024 were analyzed. Online ART for cervical cancer was applied in 350 external beam radio

SUBMITTER: Qi Y 

PROVIDER: S-EPMC12682542 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature