Abbreviated dynamic total-body [¹⁸F]FDG PET/CT protocols for predicting response in locally advanced non-small cell lung cancer via Patlak-Ki analysis.

ABSTRACT:

Background

Integrating immunotherapy with chemotherapy and radiotherapy has revolutionized the treatment of locally advanced non-small cell lung cancer (LA-NSCLC), but challenges persist in accurately assessing treatment responses. This study investigates the use of abbreviated scan protocols for dynamic total body [¹⁸F]fluorodeoxyglucose positron emission tomography/computed tomography ([¹⁸F]FDG PET/CT) to enhance clinical feasibility while maintaining diagnostic accuracy for predicting responses to induction immuno-chemotherapy.

Methods

Eligible LA-NSCLC patients scheduled for two cycles of induction immuno-chemotherapy were included and stratified into a testing group and a validation group. In the testing group, three abbreviated dynamic total body

SUBMITTER: Zheng S 

PROVIDER: S-EPMC12682553 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature