7T MRI quantitative susceptibility mapping for magnetic resonance-guided focused ultrasound thalamotomy: methodology and anatomo-clinical correlations in a retrospective pilot study.

ABSTRACT: Ventral intermediate nucleus (VIM) thalamotomy is an effective treatment for essential tremor (ET). It can be performed incisionlessly by transcranial magnetic resonance-guided focused ultrasound (MRgFUS), aiming for accurate targeting and thermal dose control. Conventional magnetic resonance imaging (MRI) sequences performed at 1.5T or 3T provide limited case-specific information on the topology of intra-thalamic sub-nuclei. Quantitative susceptibility mapping (QSM) MRI enhances the visualization of subcortical structures by leveraging the magnetic properties of tissues, typically the iron content and the myelin microstructure. QSM may help depict the high-intensity focused ultrasound (HIFU) lesion's position and extent relative to the thalamic sub-nuclei, and correlate this information w

SUBMITTER: Botta D 

PROVIDER: S-EPMC12682564 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature