Regional cortical network atrophy predicts progression to dementia in the Lewy body diseases.

ABSTRACT:

Introduction

The timeline from symptom onset to the loss of independent functioning varies across patients with Lewy body disease (LBD). Here, we investigate whether the magnitude of cortical atrophy within functional networks that subserve cognitive and affective functions has utility in predicting progression to dementia in LBD.

Methods

Forty-six LBD patients with intact instrumental and basic activities of daily living at baseline underwent brain magnetic resonance imaging scans and longitudinal clinical assessments. Cortical atrophy was estimated in LBD patients relative to an amyloid-negative control group.

Results

Multivariate Cox regression analysis demonstrated that atrophy in the affective salience and limbic networks, but not in cognitive, motor, or visual n

SUBMITTER: Ye R 

PROVIDER: S-EPMC12682588 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature