Feasibility of early tacrolimus initiation in haploidentical-PBSCT with post-transplant cyclophosphamide after melphalan-based conditioning regimen.

ABSTRACT: In haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide (PTCy-haplo), early initiation of calcineurin inhibitors may affect transplant outcome by inducing CD8⁺ transient exhaustion-like T cells which are important for chronic graft-versus-host disease and graft-versus-leukemia/lymphoma effects based on a murine model. However, to our best knowledge, there has been no report about modification of fludarabine (Flu)/melphalan (Mel)-based PTCy-haplo in a real-world setting. To evaluate the impact of early tacrolimus (TAC) initiation on outcomes, we retrospectively analyzed 19 patients at our institution between April 2017 and March 2024. The incidence and grade of cytokine release syndrome (CRS) were low (31.6% and all grades ≤ 2). In addit

SUBMITTER: Kitamura W 

PROVIDER: S-EPMC12682609 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature