Therapy-related Myeloid Neoplasms After Autologous Stem Cell Transplantation for Lymphoma: A Single-Center Experience.

ABSTRACT: Despite advances in lymphoma treatment, autologous hematopoietic stem cell transplantation (auto-HCT) remains essential in regions with limited access to novel therapies. Improved survival post-auto-HCT has led to an increased incidence of therapy-related myeloid neoplasms (t-MN). We conducted a retrospective analysis of adult patients (≥18 years) who underwent auto-HCT for lymphoma at King Hussein Cancer Center in Jordan between 2003 and 2020 with the goal of evaluating characteristics and outcomes of patients developing t-MN post-auto-HCT. We identified 407 patients with a median follow-up of 5.8 years. The median age at auto-HCT was 34.6 years, 54.9% were males, 65.3% had Hodgkin lymphoma, and 41.1% were refractory to first-line treatment. dexamethasone, ara-C, cisplatin (DHAP) was the

SUBMITTER: Yaseen A 

PROVIDER: S-EPMC12682612 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature