Plasma corin levels provide minimal prognostic utility in left atrial reverse remodeling after catheter ablation of atrial fibrillation: an observational study.

ABSTRACT:

Objective

This study aims to assess the impact of plasma corin levels on left atrial reverse remodeling (LARR) in patients with atrial fibrillation (AF) after catheter ablation (CA).

Methods

This prospective, single-center, observational study included 335 patients undergoing first CA of AF. All patients underwent at least two echocardiographic examinations at intervals of ≥3 months. Corin was measured before and 1 day after CA. LARR was defined as a reduction of ≥20% in left atrial volume index.

Results

After a median of 29.53 months of follow-up, 94 patients exhibited LARR. The plasma corin concentrations drawn pre- and post-procedure in the LARR group were 442.85 [241.25, 631.68] and 516.83 [362.4,697.84] pg/mL, and those were significantly higher than those in the

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12682628 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature