Case Report: Blood single-cell analysis of a IVB high-grade serous ovarian cancer patient presenting a favorable prognosis.

ABSTRACT:

Background

High-grade serous ovarian cancer (HGSOC) diagnosed at stage IVB typically carries a poor prognosis. Here, we describe a rare case of with an exceptional and sustained response to therapy. To explore potential drivers of this favorable outcome, we combined clinical evaluation with molecular profiling of liquid biopsy samples.

Methods

We employed a multi-platform liquid biopsy approach in peripheral blood samples collected preoperatively. Bulk RNA sequencing was performed on platelet RNA, while single-cell RNA sequencing (scRNA-seq) profiled peripheral blood mononuclear cells (PBMCs). Additionally, circulating tumor cells were identified using imaging flow cytometry (imFC).

Results

Single-cell transcriptomic analysis identified two candidate CTCs (Circulating

SUBMITTER: Wolanska M 

PROVIDER: S-EPMC12682629 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature