Global, regional and national burden of colorectal cancer and its risk factors, 1990-2021: a systematic analysis for the GBD 2021.

ABSTRACT:

Importance

Colorectal cancer (CRC) constitutes a significant segment of the global cancer burden, thereby warranting an in-depth epidemiological appraisal to inform strategic public health interventions and resource allocation. Previous studies, such as those based on the GBD 2019 dataset, have provided valuable insights into the CRC burden. However, they have limitations in terms of data recency, regional granularity, and comprehensive risk factor analysis.

Objective

This research seeks to undertake a thorough analysis of the burden of CRC at global, regional, and national levels, along with its associated risk factors, spanning the period from 1990 to 2021. This analysis will employ data sourced from the Global Burden of Disease (GBD) 2021 study, addressing limitations in

SUBMITTER: Zeng X 

PROVIDER: S-EPMC12682633 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature