Disruption of the gut bile acid-microbiota axis precedes severe bronchopulmonary dysplasia in preterm infants.

ABSTRACT:

Background

Bronchopulmonary dysplasia (BPD) remains a major cause of morbidity in preterm infants, yet current diagnostic criteria are delayed and underlying mechanisms are incompletely defined. Evidence suggests that intestinal dysbiosis may influence pulmonary outcomes via the gut-lung axis, but the metabolic mediators of this interaction remain unclear.

Methods

We conducted a prospective cohort study of 50 preterm infants (≤ 32 weeks gestation), stratified by BPD severity at 36 weeks. Stool samples collected on postnatal day 7 underwent 16S rRNA sequencing and targeted bile acid metabolomics. Differential features were identified via multivariate statistics and LEfSe. Spearman correlation analysis explored bile acid-microbiota interactions. An interpretable machine learni

SUBMITTER: Yu H 

PROVIDER: S-EPMC12682640 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature