Revealing the genetic basis of coat color in Tibetan sheep through selective sweep and transcriptomic analyses.

ABSTRACT:

Background and objective

Coat color is an important economic trait in animal husbandry and plays a crucial role in the adaptability of animal. As a key economic trait in high-altitude areas, the genetic mechanisms regulating coat color in Tibetan sheep are not fully understood.

Methods

In order to explore the genetic basis of coat color in Tibetan sheep, this study focused on white-coated Plateau Tibetan sheep (PT) and black-coated Guinan black fur sheep (GB). Using whole genome sequencing (10× coverage), transcriptomic analysis, Sanger sequencing, and protein structure prediction to identify candidate genes and molecular markers associated with coat color.

Results

In this study, a total of 9.28 million SNPs were annotated from whole-genome sequencing. Compared with t

SUBMITTER: Li X 

PROVIDER: S-EPMC12682660 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature