The bidirectional association between obstructive sleep apnea and diabetic kidney disease: systematic review and meta-analysis.

ABSTRACT:

Objective

This study aims to comprehensively explore the bidirectional association between obstructive sleep apnea (OSA) and diabetic kidney disease (DKD) through a systematic review and meta-analysis.

Method

Systematically search for relevant literature on the association between OSA and DKD published from database inception to September 2025. Searches were performed in the Cochrane Library, PubMed, Embase, and Web of Science. Study quality was assessed with the Newcastle-Ottawa Scale (NOS). Meta-analysis, sensitivity analysis, and publication bias assessment were conducted using Review Manager 5.4, while R software was employed to calculate prediction intervals. The certainty of evidence was evaluated using the GRADE (Grading of Recommendations Assessment, Development, and

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12682665 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature