Association between zinc status and autism spectrum disorder in children and adolescents: a systematic review and meta-analysis of case-control studies.

ABSTRACT:

Background

This study aimed to further corroborate a previously reported connection between zinc nutritional status and the occurrence of autism spectrum disorder (ASD) among children and adolescents.

Methods

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, a systematic review and meta-analysis was conducted. The PubMed, Embase, Web of Science, Scopus, and PsyclNFO databases were searched for all relevant case-control studies published until January 2024. Cohen's kappa was computed to assess reviewer agreement. This meta-analysis used a random-effects model to summarize the overall association between zinc levels and ASD. The Q-test and I² statistics were used to evaluate the heterogeneity of the studies, w

SUBMITTER: Liu H 

PROVIDER: S-EPMC12682681 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature