Caprine herpes virus-1 reduces cell viability and enhances chemosensitivity in breast cancer cells.

ABSTRACT:

Introduction

Oncolytic viruses (OVs) are promising therapeutic agents in oncology that directly lyse tumor cells, modulate the immune response, and alter the tumor microenvironment. Non-human OVs offer advantages over their human counterparts, such as being non-pathogenic in humans and lacking pre-existing immunity. In previous studies, we demonstrated that a non-human caprine herpesvirus 1 (CpHV-1) effectively kills various human cancer cell lines. In this study, we evaluate CpHV-1's antitumor effects across different breast cancer (BC) cell lines and its potential synergy with FDA-approved BC therapies.

Methods

We assessed the effects of CpHV-1 on BC cell viability and clonogenic potential, cell cycle regulation, and apoptosis in MCF-7, T47D, SKBR3, and MDA-MB-468 cell lin

SUBMITTER: Iannuzzi CA 

PROVIDER: S-EPMC12682693 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature