Bisphosphonates loaded nanoparticles in microparticles: a potential macrophage targeting and repolarizing drug delivery system.

ABSTRACT: Bisphosphonates (BPs) are widely used in treating bone-related conditions, with emerging evidence supporting their potential in treating both skeletal and extra-skeletal diseases. However, their clinical utility is limited by high cytotoxicity, particularly toward macrophages, leading to immune system disruption upon frequent use. This limitation highlights the need for an effective drug delivery system. While nanoparticle formulations improve pharmacokinetics and biodistribution, they often suffer from limited drug loading capacity, poor sustained-release ability, and increased cytotoxicity due to their rapid and excessive intracellular uptake.Here, we present a multifunctional formulation, composed of calcium-zoledronic acid nanoparticles (CaZol NP) encapsulated within polymeric micropar

SUBMITTER: Sagoe PNK 

PROVIDER: S-EPMC12682720 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature