Pregnancy outcomes in women with anti-β2-glycoprotein I/human leukocyte antigen-DR autoantibodies receiving assisted reproductive technology: a prospective cohort study.

ABSTRACT:

Objective

This study aimed to assess whether anti-β2-glycoprotein I (β2GPI)/human leukocyte antigen (HLA)-DR autoantibodies are associated with pregnancy outcomes in women with infertility receiving assisted reproductive technology (ART) in relation to antithrombotic therapies.

Methods

In this multicenter prospective cohort study, levels of anti-β2GPI/HLA-DR autoantibodies were measured in 194 women with infertility, who subsequently received embryo transfer (ET). The rates of clinical pregnancy, biochemical pregnancy loss, live birth, and miscarriage were assessed in relation to antibody positivity and antithrombotic treatments. The primary outcome was to evaluate how antithrombotic treatments were associated with pregnancy outcomes in women with anti-β2GPI/HLA-DR antibodie

SUBMITTER: Ono Y 

PROVIDER: S-EPMC12682744 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature