Impact of tranexamic acid on hidden blood loss in intertrochanteric fractures: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Intertrochanteric fractures (IFs) are a common type of fracture in the elderly and are often associated with substantial hidden blood loss (HBL) due to trauma and surgery. Tranexamic acid (TXA) has emerged as a potential intervention to reduce perioperative bleeding. This study aimed to evaluate the safety and efficacy of TXA administration in elderly patients with IFs undergoing intramedullary nailing, through a systematic review and meta-analysis of randomized controlled trials (RCTs).

Methods

Web of Science, Cochrane Library, Embase, and PubMed were searched for relevant RCTs published from inception to January 2025. Data on HBL, total blood loss (TBL), transfusion rate, and thromboembolic events were extracted. Review Manager 5.3.5 was used to assess the safet

SUBMITTER: Meng Y 

PROVIDER: S-EPMC12682745 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature