Exuberant long noncoding RNA expression may sculpt Igh locus topology.

ABSTRACT: Diverse Igh repertoires require successful V(D)J recombination allowing B cell receptor expression and Ig secretion for humoral immune responses. Igh locus contraction has been implicated in generating spatial proximity between distal V_H segments and the recombination center via cohesin mediated loop extrusion. However, it remains unclear why some distal V_H segments recombine with high frequency while other more proximal V_H are rarely used. Long non-coding RNAs (lncRNAs) have emerged as regulators of cellular development, differentiation and gene expression. Here we report exceptionally high expression of lncRNAs at the Igh locus and other AgR loci engaged in V(D)J recombination. A tight correlation was found between positions of multi-exonic lncRNAs, Igh e

SUBMITTER: Drake EB 

PROVIDER: S-EPMC12682764 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature