The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies.

ABSTRACT:

Background

The global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rising sharply, driven by modern lifestyle and dietary changes. As MASLD threatens public health, exploring effective treatments is urgent. Curcumin may benefit MASLD by reducing inflammation and oxidative stress, but evidence reliability remains unclear. This systematic review and meta-analysis aims to evaluate curcumin's effects in MASLD via animal studies.

Methods

Relevant animal studies were searched in PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang Database. Two researchers screened literature and extracted data; discrepancies were resolved via consultation. The SYstematic Review Center for Laboratory animal Experimentation

SUBMITTER: Li X 

PROVIDER: S-EPMC12682766 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature