Long-term multicomponent exercise enhances functional mobility in early-stage Parkinson's disease: a 48-month retrospective cohort study.

ABSTRACT:

Background

Long-term effects of structured exercise on functional capacity in Parkinson's disease (PD) remain poorly understood.

Objective

To investigate the impact of a 48-month multicomponent exercise program on mobility, aerobic capacity, and muscle mass in individuals with early-stage PD, and to examine baseline predictors of functional performance.

Methods

Thirty-three patients with PD (Hoehn & Yahr stages 1-2) participated in a supervised, thrice-weekly program including aerobic, resistance, balance, and flexibility exercises. Assessments at baseline and 48 months included the Timed Up and Go (TUG), Six-Minute Walk Test (6MWT), peak oxygen uptake (VO₂peak), and muscle mass. Minimal detectable change (MDC), effect sizes, and linear regressions were com

SUBMITTER: Moura M 

PROVIDER: S-EPMC12682783 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature