Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and experimental evaluation.

ABSTRACT:

Introduction

Pharmacological studies have confirmed that Cepharanthine (CEP) can exert anti-inflammatory, antioxidant and anti-fibrotic effects. However, there is no systematic study on whether CEP targets and regulates the core pathological link of benign prostatic hyperplasia (BPH) - matrix hyperplasia.

Methods

First, the CEP structure was obtained through PubChem. Combined with BPH targets from the GeneCards/OMIM/TTD database, potential targets were obtained by intersection using Venny 2.1. Then, the PPI network was constructed using STRING, and top 20 core targets were identified using Cytoscape 3.9.1. GO/KEGG enrichment analysis was performed using the DAVID database. Based on the CB-Dock platform, CEP was molecularly docked with key targets, the protein structure was d

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12682793 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature