Defining the optimal Ki67 cutoff values for survival prediction in neoadjuvant chemotherapy-treated patients with breast cancer.

ABSTRACT:

Background

The rising incidence of breast cancer underscores the need for precise prognostic assessment following neoadjuvant chemotherapy (NAC). Ki67 is widely utilized for prognostic evaluation. However, its clinical applicability remains debated, particularly regarding the optimal cutoff threshold. This study aims to establish the optimal Ki67 cutoff value and evaluate its prognostic significance in predicting survival outcomes in patients with breast cancer undergoing NAC.

Methods

A retrospective analysis was performed on 255 patients with breast cancer who received NAC between 2011 and 2024. The optimal Ki67 cutoff value was determined using maximally selected rank statistics. Kaplan-Meier survival analysis was used to evaluate the impact of Ki67 on disease-free surviva

SUBMITTER: Jiang C 

PROVIDER: S-EPMC12682876 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature