Quantitative proteomic analysis reveals potential serum diagnostic markers for colorectal adenoma.

ABSTRACT:

Introduction

Colorectal cancer (CRC) is one of the leading causes of cancer-related death, and most CRCs arise from colorectal adenomas. Early detection and removal of precancerous lesions during the adenoma-carcinoma sequence can significantly reduce CRC risk. However, current clinical practice lacks rapid, noninvasive screening tools for reliable adenoma detection.

Methods

Proteomic analysis was performed on serum samples from patients with inflammatory polyps (non-neoplastic), patients with adenomas, and healthy controls to identify key differentially expressed proteins capable of distinguishing adenoma patients. The alterations in these candidate proteins were further validated by ELISA to evaluate their potential as diagnostic biomarkers for colorectal adenoma.

Resul

SUBMITTER: Yu C 

PROVIDER: S-EPMC12682900 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature