Circadian Blood Pressure Phenotyping Identifies Subtype-Specific Risk and Outcomes in Acute Ischemic Stroke: A Prospective Study.

ABSTRACT: Circadian organization of blood pressure (BP) is increasingly recognized as a determinant of vascular risk, but its role in acute ischemic stroke (AIS) remains undefined. We investigated whether early circadian BP phenotypes derived from high-frequency monitoring predict short- and long-term outcomes after AIS. In a prospective cohort of 529 patients with AIS, BP was recorded-noninvasively or via arterial line-during the first 72 h. Circadian parameters were extracted using cosinor analysis, and exploratory clustering was applied to identify recurrent BP patterns. Associations with early neurological deterioration (END), symptomatic intracerebral hemorrhage (sICH), 90-day functional outcome, mortality, and 1-year major adverse cardiovascular events (MACE) were assessed using multivariable

SUBMITTER: Boettger P 

PROVIDER: S-EPMC12682914 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature