Impaired inactive limb blood flow regulation in adults with multiple sclerosis during sympathoexcitatory stimuli.

ABSTRACT: Individuals with multiple sclerosis (MS) exhibit reduced physical capacity, partly due to autonomic dysfunction. Autonomic impairments are well documented, but peripheral blood flow regulation during exercise remains unclear. We compared peripheral vascular responses to dynamic handgrip exercise, with and without a mild sympathoexcitatory stimulation, in individuals with and without MS. Twenty-one individuals with MS (M/F: 4/17; 43 ± 10 yrs) and 27 individuals without MS (M/F: 10/17; 28 ± 6 yrs) completed a 5-min supine dynamic handgrip exercise at 15% and 30% maximal voluntary contraction, which were repeated during -20 mmHg lower body negative pressure (LBNP). BP was assessed using finger photoplethysmography, and brachial artery blood flow via ultrasound. Individuals with MS had increas

SUBMITTER: Sherman SR 

PROVIDER: S-EPMC12682930 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature