Beta Power Response After Levodopa Intake in Parkinson's Disease Patients With Chronic Sensing-Enabled Deep Brain Stimulation.

ABSTRACT:

Objective

In Parkinson's disease (PD), the power of beta oscillations (± 13-30 hertz [Hz]) from subthalamic nucleus (STN) local field potentials (LFPs) is associated with motor symptoms. Beta power can be used for adaptive deep brain stimulation (aDBS) algorithms based upon symptom fluctuations. The time course of beta power modulations after levodopa intake at home remains to be described.

Methods

Ten-minute averages of beta peak power were recorded in 33 patients with PD treated with STN-DBS for a median duration of 134 days during the titration phase. Median beta power after scheduled medication intakes (n = 24,103) and the effects of peak frequency, stun effect, stimulation amplitude, levodopa dose, and preoperative levodopa response were analyzed using cluster-based per

SUBMITTER: de Neeling MGJ 

PROVIDER: S-EPMC12682937 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature