Comparative Effectiveness and Safety of Various Anticoagulation Regimens for Portal Venous Thrombosis in Cirrhosis: A Systematic Review and Network Meta-Analysis.

ABSTRACT: BackgroundPortal venous thrombosis (PVT) is a serious complication in cirrhosis, with management debated due to differing anticoagulant guidelines. This network meta-analysis assessed various anticoagulants for PVT in cirrhotic patients.MethodsPubMed, Cochrane Central, and ScienceDirect were searched till May 2025. A frequentist network meta-analysis was conducted in RStudio version 4.3.3. The ranking was based on P-scores.ResultsNineteen studies were included in the analysis. Direct oral anticoagulants (DOACs) (RR = 2.38; 95%CI:[1.17, 4.85]; p = 0.02), fondaparinux (RR = 18.16; 95%CI:[2.09, 158.13]; p = 0.009), low-molecular-weight heparin (LMWH) (RR = 11.96; 95%CI:[1.58, 90.79]; p = 0.01), LMWH-Warfarin sequential therapy (RR = 2.32; 95%CI:[1.01, 5.31]; p = 0.04), and Vitamin K antagonis

SUBMITTER: Abideen ZU 

PROVIDER: S-EPMC12682983 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature