Microbiome and metabolome changes in laying hens induced by dietary epsilon-polylysine.

ABSTRACT: Epsilon-polylysine (ε-PL) is a natural antimicrobial peptide that has been broadly applied in the food industry as a preservative. The effects of ε-PL on the intestinal microbiota, animal metabolism, and its potential as a "new feed additive" require further exploration. In this study, ninety Hy-Line Brown laying hens were randomly divided into three groups. Egg-laying performance, egg quality, and liver parameters were measured; expression of gut barrier, immunity, and ferroptosis related genes in each intestinal segment were detected; microbiome and metabolomic analyses were performed. The results demonstrated that dietary ε-PL supplementation significantly increased average egg weight and egg quality (P < 0.05). It also markedly, ε-PL supplementation significantly increased the villus h

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12683153 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature